In vitro association of type III collagen with elastin and with its solubilized peptides.

Rabaud, M; Lefebvre, F; Ducassou, D · Biomaterials · 1991

basic_science · Level V

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Abstract

Elastin fibres or elastin solubilized peptides associated with type III collagen, under physiological conditions, to form a gel-like substance. The gel cohesion could be markedly improved either by desiccation process (gently air-dried rather than lyophilized) or by addition of adhesive connective proteins such as fibronectin, laminin and type IV collagen. They conferred to the material the composition and the structural appearance of typical basement membrane-like structure. Their properties enable us to investigate the biomaterial in several domains.

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