From ER to Eph receptors: new roles for VAP fragments.
editorial · Level V
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- Record sourced from PubMed, PMID 18555770.
- Also identified by DOI 10.1016/j.cell.2008.05.028.
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Abstract
Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Receptors, Eph Family
- Vesicular Transport Proteins