ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18565989.
- Also identified by DOI 10.1093/bioinformatics/btn317 and PMC identifier 2732213.
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Abstract
Many important problems in biology involve complex traits affected by multiple coding or regulatory parts of the genome. How well the underlying genetic architecture can be inferred by statistical methods such as mapping and association studies are active research areas. ForSim is a flexible forward evolutionary simulation tool for exploring the consequences of evolution by phenotype, whereby demographic, chance, behavioral and selective effects mold genetic architecture. Simulation is useful for exploring these issues as well as the choice of study design inferential methods. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Artifacts
- Chromosome Mapping
- Evolution, Molecular
- Models, Genetic
- Quantitative Trait Loci
- Quantitative Trait, Heritable
- Software