Pediatric human immunodeficiency virus infection and circulating IgD+ memory B cells.
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- Record sourced from PubMed, PMID 18582200.
- Also identified by DOI 10.1086/590215.
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Abstract
Levels of circulating naive and memory B cells were measured in human immunodeficiency virus (HIV)-infected children and control subjects to determine whether the irreversible depletion of memory B cells described in HIV-infected adults occurs in children with HIV infection. Depletion of circulating IgD+ memory B cells was seen in HIV-infected children despite control of the HIV load with highly active antiretroviral therapy (HAART) (P =. 04). IgD+ memory B cell percentages did not correlate with CD4+ cell percentages (P =. 027) or disease duration (P =. 026). Naive/transitional and IgD- memory B cell numbers were not affected. Pediatric HIV infection is associated with selective depletion of circulating IgD+ memory B cells despite control of the HIV load with HAART.
Medical subject headings
- Antiretroviral Therapy, Highly Active
- B-Lymphocytes
- HIV Infections
- HIV-1
- Immunoglobulin D
- Immunologic Memory