Stop-flow lithography to generate cell-laden microgel particles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18584079.
- Also identified by DOI 10.1039/b804234a and PMC identifier 2790079.
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Abstract
Encapsulating cells within hydrogels is important for generating three-dimensional (3D) tissue constructs for drug delivery and tissue engineering. This paper describes, for the first time, the fabrication of large numbers of cell-laden microgel particles using a continuous microfluidic process called stop-flow lithography (SFL). Prepolymer solution containing cells was flowed through a microfluidic device and arrays of individual particles were repeatedly defined using pulses of UV light through a transparency mask. Unlike photolithography, SFL can be used to synthesize microgel particles continuously while maintaining control over particle size, shape and anisotropy. Therefore, SFL may become a useful tool for generating cell-laden microgels for various biomedical applications.
Medical subject headings
- Cells
- Hydrogels
- Microfluidic Analytical Techniques