Rat middle cerebral artery occlusion using an intraluminal thread technique.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1858530.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A modification of the previous methods of producing cerebral ischaemia in rats (Koizumi et al., Longa et al.), using an intraluminal thread technique, is described. The middle cerebral artery is occluded by introducing a simple 3-0 nylon thread (0.20-0.249 mm in diameter) through the internal carotid artery in the neck. It has been proven that with this method reproducible focal cerebral ischaemia can be achieved which resembles human stroke. Therefore this simple and relatively non-invasive model is suitable for the pathophysiological investigation of ischaemic stroke and the testing of potential therapies.
Medical subject headings
- Brain Ischemia
- Disease Models, Animal