A lexicon for homeodomain-DNA recognition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18585344.
- Also identified by DOI 10.1016/j.cell.2008.06.008.
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Abstract
Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work (Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo.
Medical subject headings
- DNA
- Homeodomain Proteins