Forging new ties between E. coli genes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18585345.
- Also identified by DOI 10.1016/j.cell.2008.06.003 and PMC identifier 2806683.
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Abstract
A recent study in Nature (Isalan et al., 2008) has examined the effects of systematically adding new transcriptional interactions in the bacterium Escherichia coli. Surprisingly, the majority of the engineered connections have no effect on growth, and in some cases the new connections enhance fitness. These findings reveal insights into the robustness and evolvability of gene networks.
Medical subject headings
- Escherichia coli
- Gene Regulatory Networks