LUSH shapes up for a starring role in olfaction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18585346.
- Also identified by DOI 10.1016/j.cell.2008.06.010.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In the fruit fly Drosophila, odorant-binding proteins are secreted into the fluid that bathes olfactory neurons. Laughlin et al. (2008) now challenge the assumption that the odorant-binding protein LUSH passively transports its pheromone to a specific olfactory receptor. Instead, LUSH undergoes a conformational change upon pheromone binding that is sufficient for neuronal activation.
Medical subject headings
- Drosophila melanogaster
- Olfactory Receptor Neurons
- Receptors, Odorant
- Smell