Hedgehog nanopackages ready for dispatch.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18585347.
- Also identified by DOI 10.1016/j.cell.2008.06.011.
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Abstract
Hedgehog proteins are intercellular long-range signaling molecules that spread within tissues and activate gene expression during development. Vyas et al. (2008) propose that Hedgehog forms nanometer-sized oligomers that localize in proteoglycan-rich clusters at the surface of cells expressing Hedgehog. This nanoscale organization and enrichment in clusters ensures that Hedgehog is able to spread and activate signaling over many cell diameters.
Medical subject headings
- Drosophila
- Hedgehog Proteins
- Signal Transduction