Team effort by TRAPP forces a nucleotide fumble.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18585348.
- Also identified by DOI 10.1016/j.cell.2008.06.012.
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Abstract
TRAPPI is a multisubunit protein complex on the Golgi that activates the small GTPase Ypt1p to facilitate the receipt of transport vesicles inbound from the endoplasmic reticulum. Cai et al. (2008) now present structural and biochemical analyses of yeast TRAPPI in a complex with Ypt1p revealing a unique mechanism by which TRAPPI catalyzes guanine nucleotide exchange.
Medical subject headings
- Guanine Nucleotides
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Vesicular Transport Proteins
- rab GTP-Binding Proteins