Fine tuning of hepcidin expression by positive and negative regulators.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18590684.
- Also identified by DOI 10.1016/j.cmet.2008.06.009.
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Abstract
Hepcidin, the systemic regulator of iron homeostasis is activated by proteins responsible for hereditary hemochromatosis, bone morphogenetic proteins (BMPs), and inflammatory cytokines. Three recent publications now identify a novel hepcidin suppressor, the transmembrane serine protease TMPRSS6 (also known as matriptase-2), which is required to sense iron deficiency.
Medical subject headings
- Antimicrobial Cationic Peptides
- Membrane Proteins
- Serine Endopeptidases