The double life of Irs.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18590687.
- Also identified by DOI 10.1016/j.cmet.2008.06.010 and PMC identifier 2712626.
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Abstract
The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Intracellular Signaling Peptides and Proteins
- Phosphoproteins