Targeted ablation of the vitamin D 1alpha-hydroxylase gene: getting to the heart of the matter.
Level V
Where this comes from
- Record sourced from PubMed, PMID 18591942.
- Also identified by DOI 10.1038/ki.2008.219.
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Abstract
Targeted gene ablation technology has uncovered biological mechanisms that have led to important therapeutics in humans. In a study by Zhou et al., ablation of the 1alpha-hydroxylase gene led to hypertension, cardiac hypertrophy, and systolic dysfunction, and this cardiac phenotype was rescued with exogenous 1,25-dihydroxyvitamin D administration.
Medical subject headings
- Cardiomegaly
- Hypertension
- Vitamin D