HNF1beta and defective nephrogenesis: a role for interacting partners?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18591944.
- Also identified by DOI 10.1038/ki.2008.250.
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Abstract
The genetic program controlled by transcription factors can be modulated by multiple mechanisms. Binding of coactivators or corepressors, for example, can modulate the transcription of target genes. Dudziak and colleagues identified novel HNF1beta-interacting proteins that, when overexpressed, affect nephrogenesis. These results could improve our understanding of the way HNF1beta controls kidney development.
Medical subject headings
- Gene Expression Regulation, Developmental
- Hepatocyte Nuclear Factor 1-beta
- Kidney
- Organogenesis