The classic: integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts: (RNA tumor viruses/reassociation kinetics/duck cells). 1973.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18597148.
- Also identified by DOI 10.1007/s11999-008-0355-8 and PMC identifier 2493013.
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Abstract
A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated.
Medical subject headings
- Rous sarcoma virus
- Sarcoma, Avian
- Virus Integration