Dependence of antibody-mediated presentation of antigen on FcRn.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18599440.
- Also identified by DOI 10.1073/pnas.0801717105 and PMC identifier 2453734.
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Abstract
The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.
Medical subject headings
- Antigen Presentation
- Histocompatibility Antigens Class I
- Immunoglobulin G
- Receptors, Fc