Interchromosomal huddle kickstarts antiviral defense.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18614003.
- Also identified by DOI 10.1016/j.cell.2008.06.041.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Long-distance chromosomal interactions are emerging as a potential mechanism of gene expression control. In this issue, Apostolou and Thanos (2008) describe how viral infection elicits interchromosomal associations between the interferon-beta (IFN-beta) gene enhancer and DNA binding sites of the transcription factor NF-kappaB, resulting in the initiation of transcription and an antiviral response.
Medical subject headings
- Chromosomes
- Enhancer Elements, Genetic
- Transcription, Genetic
- Virus Diseases