Clearing the way for unpaused polymerases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18614004.
- Also identified by DOI 10.1016/j.cell.2008.06.031.
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Abstract
Heat shock loci in the polytene chromosomes of the fruit fly Drosophila undergo a characteristic change in appearance that coincides with the onset of gene expression. Petesch and Lis (2008) now show that nucleosomes are lost across the entire Hsp70 locus in an initial wave that precedes transcription by RNA polymerase II.
Medical subject headings
- Drosophila
- Drosophila Proteins
- HSP70 Heat-Shock Proteins
- Heat-Shock Response
- Nucleosomes
- RNA Polymerase II