Rab5 and rac team up in cell motility.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18614005.
- Also identified by DOI 10.1016/j.cell.2008.06.039.
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Abstract
Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.
Medical subject headings
- Cell Movement
- Proto-Oncogene Proteins c-akt
- rab5 GTP-Binding Proteins