Multiple modes of engrailed regulation in the progression towards cell fate determination.
basic_science · Level V
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- Record sourced from PubMed, PMID 1861720.
- Also identified by PMC identifier 2755087.
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Abstract
The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.
Medical subject headings
- Cell Differentiation
- Drosophila
- Gene Expression Regulation