Glomerular filtration: the charge debate charges ahead.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18626493.
- Also identified by DOI 10.1038/ki.2008.260.
- No licence information is recorded for this record.
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Abstract
The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
Medical subject headings
- Glomerular Filtration Rate
- Heparan Sulfate