RLIP76 and Cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18628450.
- Also identified by DOI 10.1158/1078-0432.CCR-08-0145 and PMC identifier 2919285.
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Abstract
RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds.
Medical subject headings
- ATP-Binding Cassette Transporters
- GTPase-Activating Proteins
- Neoplasms
- Signal Transduction