Multisystem failure and hepatic microvesicular fatty metamorphosis associated with tolmetin ingestion.

Shaw, G R; Anderson, W R · Arch Pathol Lab Med · 1991

case_report · Level V

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Abstract

Multisystem toxicity including both renal and hepatic failure has been reported with the use of nonsteroidal anti-inflammatory drugs. We report a fatal case of multisystem failure associated with tolmetin ingestion in a 15-year-old girl. Microvesicular fatty change was found in the liver at autopsy. To our knowledge, this is the first reported case of nonsteroidal anti-inflammatory drug-associated multisystem failure to have this histopathologic finding.

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