Cell competition and its possible relation to cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18632598.
- Also identified by DOI 10.1158/0008-5472.CAN-07-6348.
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Abstract
Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.
Medical subject headings
- Gene Expression Regulation, Neoplastic
- Neoplasms