Structural comparisons of class I phosphoinositide 3-kinases.
review · Level V
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- Record sourced from PubMed, PMID 18633356.
- Also identified by DOI 10.1038/nrc2443 and PMC identifier 2847604.
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Abstract
Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell growth. One of these kinases, PI3Kalpha, is frequently mutated in diverse tumour types. The recently determined structure of PI3Kalpha reveals features that distinguish this enzyme from related lipid kinases. In addition, wild-type PI3Kgamma differs from PI3Kalpha by a substitution identical to a PI3Kalpha oncogenic mutant (His1047Arg) that might explain the differences in the enzymatic activities of the normal and mutant PI3Kalpha. Comparison of the PI3K structures also identified structural features that could potentially be exploited for the design of isoform-specific inhibitors.
Medical subject headings
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)