Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.
case_control · Level III
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Abstract
To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. CD14 and TLR4 showed an association with AS in the Finns only.
Medical subject headings
- Genetic Predisposition to Disease
- Lipopolysaccharide Receptors
- Polymorphism, Single Nucleotide
- Spondylitis, Ankylosing
- Toll-Like Receptor 4