Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18640082.
- Also identified by DOI 10.1016/j.actbio.2008.05.027.
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Abstract
In the present work we synthesized inorganic oxide nanoparticle carriers of platinum compounds and tested their therapeutic effect on animal models in which C6 glioma cells have been inoculated. TiO(2)-containing Pt(NH(3))(4)Cl(2) complexes were synthesized using sol-gel methods. The platinum species are chemically bonded to the TiO(2) carrier, as shown by Fourier transform infrared spectroscopy of probe molecules. Treatment with TiO(2)-Pt nanoparticles reduces tumour growth rate by up to 56%, showing that a synergistic effect exists between the TiO(2) carrier and the platinum drug.
Medical subject headings
- Biocompatible Materials
- Brain Neoplasms
- Glioblastoma
- Platinum
- Titanium