Can tumor growth be further inhibited by combining drugs such as bortezomib with image-guided interventional oncologic procedures?
other · Level V
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- Record sourced from PubMed, PMID 18641238.
- Also identified by DOI 10.1148/radiol.2482080719.
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Abstract
Poff et al (1) were able to demonstrate delayed tumor growth of murine squamous cell carcinoma in an orthotopic C3H murine tumor model when adding pulsed high-intensity focused ultrasound (HIFU) as an adjunctive pretreatment to bortezomib, a proteasome inhibitor. In essence, this combination therapy induced greater apoptosis than did the drug alone and enabled the achievement of equivalent efficacy with a substantial dose reduction of a potentially toxic drug.
Medical subject headings
- Antineoplastic Agents
- Boronic Acids
- Carcinoma, Squamous Cell
- Pyrazines
- Ultrasonic Therapy