Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan.

Umemura, Takeji; Tanaka, Eiji; Kiyosawa, Kendo; Kumada, Hiromitsu; Japan de novo Hepatitis B Research Group · Clin Infect Dis · 2008

retrospective_cohort · Level III

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Abstract

Hepatitis B virus (HBV) reactivation in patients with resolved HBV infection was found in 23 (4%) of 552 newly hepatitis B surface antigen-positive patients in Japan. Because one-fourth of cases develop into fulminant hepatic failure and mortality is 100%, management of HBV reactivation in patients with resolved HBV infection should be discussed.

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