S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18650379.
- Also identified by DOI 10.1073/pnas.0804852105 and PMC identifier 2492460.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Glutamate/N-methyl-d-aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this neurotoxicity reflects activation of COX-2 by S-nitrosylation after selective binding of neuronal nitric oxide synthase (nNOS) to COX-2. nNOS, via its PDZ domain, binds COX-2 with the generated NO S-nitrosylating and activating the enzyme. Selective disruption of nNOS-COX-2 binding prevents NMDA neurotoxicity.
Medical subject headings
- Cyclooxygenase 2
- N-Methylaspartate
- Receptors, N-Methyl-D-Aspartate