The role of exercise and PGC1alpha in inflammation and chronic disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18650917.
- Also identified by DOI 10.1038/nature07206 and PMC identifier 2587487.
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Abstract
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
Medical subject headings
- Exercise
- Inflammation
- Transcription Factors