Controlled encapsulation of single-cells into monodisperse picolitre drops.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18651066.
- Also identified by DOI 10.1039/b805456h and PMC identifier 2570196.
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Abstract
Encapsulation of cells within picolitre-size monodisperse drops provides new means to perform quantitative biological studies on a single-cell basis for large cell populations. Variability in the number of cells per drop due to stochastic cell loading is a major barrier to these techniques. We overcome this limitation by evenly spacing cells as they travel within a high aspect-ratio microchannel; cells enter the drop generator with the frequency of drop formation.
Medical subject headings
- Microchemistry
- Microfluidic Analytical Techniques