Initial human herpesvirus-8 rash and multicentric Castleman disease.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 18652555.
- Also identified by DOI 10.1086/590942.
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Abstract
We describe a human immunodeficiency virus-infected man with relapsing rashes and reactivation of human herpesvirus-8 (HHV-8) infection, which evolved into multicentric Castleman disease. Initial skin biopsy revealed infiltrating HHV-8-positive plasmablasts, a subset of which supported lytic infection. We document the first case, to our knowledge, of HHV-8-induced rash and suggest that circulating plasmablasts drive HHV-8 to target tissues.
Medical subject headings
- Castleman Disease
- Exanthema
- Herpesviridae Infections
- Herpesvirus 8, Human