The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 18656717.
- Also identified by DOI 10.1016/j.otohns.2008.04.032.
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Abstract
To investigate the expression and clinical significance of MMP-2, MMP-7, MMP-9, and TIMP-1 in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS). Prospective study. This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined. Expression of MMP-2 was found significantly increased in NP, whereas MMP-7 expression was found significantly increased in CRS (P < 0.001). TIMP-1 was significantly high in control group compared to CRS and NP (P < 0.001 and P = 0.002, respectively). Different regulation type of activation of MMPs has been found in these two diseases. If MMP-2 expression is intense in the mucosa, then this ends with polyp formation; if MMP-7 expression is intense, it ends with CRS or stays as CRS.
Medical subject headings
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 7
- Matrix Metalloproteinase 9
- Nasal Polyps
- Sinusitis
- Tissue Inhibitor of Metalloproteinase-1