Serotonin uptake in the blood platelets of Alzheimer's disease patients.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 1866025.
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Abstract
We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer's disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased V max was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.
Medical subject headings
- Alzheimer Disease
- Blood Platelets
- Serotonin