Effective induction of high-titer antibodies by viral vector vaccines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18660818.
- Also identified by DOI 10.1038/nm.1850 and PMC identifier 4822545.
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Abstract
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.
Medical subject headings
- Genetic Vectors
- Malaria Vaccines
- T-Lymphocytes
- Viral Vaccines