Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.
case_control · Level III
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- Record sourced from PubMed, PMID 18661559.
- Also identified by DOI 10.1002/ana.21446 and PMC identifier 8957216.
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Abstract
We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration.
Medical subject headings
- Brain
- Neurodegenerative Diseases
- Neurofibrillary Tangles
- Neurons
- alpha-Synuclein
- tau Proteins