Transverse tunneling through DNA hydrogen bonded to an electrode.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18662039.
- Also identified by DOI 10.1021/nl801646y and PMC identifier 2575003.
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Abstract
Guanidinium ions tethered to an electrode form electrical contacts to DNA via hydrogen bonding with the backbone phosphates, thus providing a sequence-independent electrical connector for native DNA submerged in an aqueous electrolyte. DNA adlayers on a guanidinium modified electrode can be imaged by scanning tunneling microscopy with tens of pS gap conductance. The image resolution suggests that multiatom contacts contribute to the tunnel conductance, so we estimate that the single-nucleotide pair conductance may be on the order of 1 pS.
Medical subject headings
- DNA