Costly mistakes: translational infidelity and protein homeostasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18662533.
- Also identified by DOI 10.1016/j.cell.2008.07.005.
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Abstract
Protein misfolding is increasingly being recognized as a key process in organismal health and disease. Drummond and Wilke (2008) show that misfolding caused by mistakes during the translation of RNA into proteins (mistranslation) also results in a strong selection pressure to optimize translational fidelity, especially for proteins that are highly expressed.
Medical subject headings
- Protein Biosynthesis
- Protein Folding
- Proteins