SIRT1 is a circadian deacetylase for core clock components.
basic_science · Level V
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- Record sourced from PubMed, PMID 18662537.
- Also identified by DOI 10.1016/j.cell.2008.07.010 and PMC identifier 3671948.
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Abstract
The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. These results broaden our understanding of the impact of cellular metabolism on the circadian system.
Medical subject headings
- Circadian Rhythm
- Sirtuins
- Trans-Activators