Successful pregnancy in a patient with severe combined immunodeficiency syndrome treated with bone marrow transplantation.

Abstract

We present the case of a patient with a history of severe combined immunodeficiency (SCID) syndrome successfully treated with bone marrow transplantation. Her resultant Rh alloimmunization complicated her first pregnancy. The patient was diagnosed with SCID syndrome after a series of opportunistic infections. The patient underwent bone marrow transplantation, receiving the graft from her haploidentical father. Once pregnant, her antepartum course was complicated by Rh alloimmunization resulting from her bone marrow transplantation, changing her blood antigen status from D-positive to D-negative. Antenatally, she was closely managed with serial middle cerebral artery Doppler measurements and delivered a healthy baby girl at term. Bone marrow transplantation in a patient with SCID syndrome resulted in Rh isoimmunization, complicating pregnancy management.