Macrophages and hypoxia in human chronic kidney disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18670402.
- Also identified by DOI 10.1038/ki.2008.225.
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Abstract
Chronic kidney disease is characterized by progressive interstitial fibrosis, reduced blood flow, and tubular atrophy, which present a common pathway of destruction irrespective of the initial underlying pathology. There is comprehensive evidence that the interactions of infiltrating macrophages with resident tissue cells play a critical role in this process. A new study now describes the correlation between macrophages, capillary density, and interstitial scarring and suggests distinct differences in early and advanced renal disease.
Medical subject headings
- Hypoxia
- Kidney
- Kidney Failure, Chronic
- Macrophages