A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18682232.
- Also identified by DOI 10.1016/j.stem.2008.07.006.
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Abstract
In a recent paper in Nature Neuroscience, Jessberger et al. (2008) report that overexpression of ASCL1 (mash1) directs adult hippocampal progenitors to adopt an oligodendrocytic fate. The effect is specific to the hippocampal niche in vivo, indicating that cell-autonomous and niche-defined factors collaborate to instruct cell fate choices.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- Dentate Gyrus
- Oligodendroglia
- Organogenesis
- Transcriptional Activation