TGFbeta and SMADs talk to NANOG in human embryonic stem cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18682233.
- Also identified by DOI 10.1016/j.stem.2008.07.011.
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Abstract
The TGFbeta/activin signaling pathway is important for the maintenance of human embryonic stem cells. In this issue of Cell Stem Cell, Xu et al. (2008) show that this pathway upregulates the expression of a key pluripotency gene NANOG through SMAD2/3.
Medical subject headings
- Embryonic Stem Cells
- Homeodomain Proteins
- Lymphotoxin-alpha
- Smad2 Protein
- Smad3 Protein