Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 18682780.
- Also identified by DOI 10.1371/journal.pone.0002891 and PMC identifier 2494944.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Several lines of evidence suggest that mitochondrial genetic factors may influence susceptibility to multiple sclerosis. To explore this hypothesis further, we re-sequenced the mitochondrial genome (mtDNA) from 159 patients with multiple sclerosis and completed a haplogroup analysis including a further 835 patients and 1,506 controls. A trend towards over-representation of super-haplogroup U was the only evidence for association with mtDNA that we identified in these samples. In a parallel analysis of nuclear encoded mitochondrial genes, we also found a trend towards association with the complex I gene, NDUFS2. These results add to the evidence suggesting that variation in mtDNA and nuclear encoded mitochondrial genes may contribute to disease susceptibility in multiple sclerosis.
Medical subject headings
- DNA, Mitochondrial
- Genetic Predisposition to Disease
- Multiple Sclerosis