Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18683988.
- Also identified by DOI 10.1021/nl801362a and PMC identifier 2910584.
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Abstract
An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
Medical subject headings
- Nanotubes, Carbon
- Neoplasms, Experimental
- Spectrum Analysis, Raman