Otx2's incredible journey.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18692461.
- Also identified by DOI 10.1016/j.cell.2008.07.029.
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Abstract
A surprising new mechanism that regulates the plasticity of postnatal neurons is reported in this issue by Sugiyama et al. (2008). These authors show in mice that visual experience triggers cell-to-cell transfer of the homeoprotein Otx2 to cortical interneurons, where it promotes maturation of inhibitory neural circuitry and opens the critical period for plasticity in the visual cortex.
Medical subject headings
- Neuronal Plasticity
- Otx Transcription Factors
- Visual Cortex