TGF-beta: a master of all T cell trades.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18692464.
- Also identified by DOI 10.1016/j.cell.2008.07.025 and PMC identifier 3677783.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A functional adaptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are generated in the thymus and maintained in the peripheral lymphoid organs. Recent studies have defined the cytokine transforming growth factor-beta (TGF-beta) as a critical regulator of thymic T cell development as well as a crucial player in peripheral T cell homeostasis, tolerance to self antigens, and T cell differentiation during the immune response. The unique mechanism of TGF-beta activation and the plasticity of TGF-beta signaling create a stage for TGF-beta to integrate signals from multiple cell types and environmental cues to regulate T cells.
Medical subject headings
- T-Lymphocytes
- Transforming Growth Factor beta