Tumors sound the alarmin(s).
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18701469.
- Also identified by DOI 10.1158/0008-5472.CAN-08-0044 and PMC identifier 2755533.
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Abstract
Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins-including the defensins, LL-37, and HMGB1-in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors.
Medical subject headings
- Antimicrobial Cationic Peptides
- Defensins
- HMGB1 Protein
- Neoplasms